abstract：:The study of controlled release and drug release devices has been dominated by considerations of the bulk or average properties of material or devices. Yet the outermost surface atoms play a central role in their performance. The objective of this article has been to characterize the surface of hydrophilic matrix tabl...

journal_title：International journal of pharmaceutics

authors： Saurí J,Suñé-Negre JM,Díaz-Marcos J,Vilana J,Millán D,Ticó JR,Miñarro M,Pérez-Lozano P,García-Montoya E

更新日期：2015-01-15 00:00:00

abstract：:Since the last decade, nanodispersed drug delivery systems gain increasingly more importance for therapeutic research fields. The forced transport to the centers of inflammation is supposed to take advantage as a novel strategic approach. Thus, the focus of this study was to investigate the applicability of ubiquinone...

journal_title：International journal of pharmaceutics

authors： Hoennscheidt C,Margaritis A,Krull R

更新日期：2015-01-15 00:00:00

abstract：:Human sodium taurocholate co-transporting polypeptide (NTCP) is the main bile acid uptake transporter in the liver with the capability to translocate xenobiotics. While its inhibitor requirements have been recently characterized, its substrate requirements have not. The objectives of this study were (a) to elucidate N...

journal_title：International journal of pharmaceutics

authors： Dong Z,Ekins S,Polli JE

更新日期：2015-01-15 00:00:00

abstract：:The study was aimed at evaluating whether the ocular hypotensive effect of melatonin (MEL) was enhanced by its encapsulation in cationic solid lipid nanoparticles (cSLN), as well as at determining the tolerability of these formulations on the ocular surface. MEL was loaded in cSLN that had already been shown to be sui...

journal_title：International journal of pharmaceutics

authors： Leonardi A,Bucolo C,Drago F,Salomone S,Pignatello R

更新日期：2015-01-15 00:00:00

abstract：:To facilitate targeting drug delivery and combined therapy, we develop titanium dioxide-encapsulated Fe3O4 nanoparticles (Fe3O4@TiO2 NPs). Titanium dioxide (TiO2), which is employed as a sonosensitizer for sonodynamic therapy (SDT), can also be used for the loading of doxorubicin (DOX). The fabricated Fe3O4@TiO2 NPs e...

journal_title：International journal of pharmaceutics

authors： Shen S,Wu L,Liu J,Xie M,Shen H,Qi X,Yan Y,Ge Y,Jin Y

更新日期：2015-01-01 00:00:00

abstract：:We have evaluated a miniaturized in vitro method, based on the μDISS Profiler™ technique that enables on-line monitoring of drug release from a 21 μl sample with 10 ml of release medium. Four model drugs in eight clinically used formulations, including both solid and non-solid drug delivery systems, were investigated....

journal_title：International journal of pharmaceutics

authors： Ahnfelt E,Sjögren E,Axén N,Lennernäs H

更新日期：2015-01-01 00:00:00

abstract：:NLC topical formulation as an alternative to oral and parenteral (IM) delivery of artemether (ART), a poorly water-soluble drug was designed. A Phospholipon 85G-modified Gelucire 43/01 based NLC formulation containing 75% Transcutol was chosen from DSC studies and loaded with gradient concentration of ART (100-750 mg)...

journal_title：International journal of pharmaceutics

authors： Nnamani PO,Hansen S,Windbergs M,Lehr CM

更新日期：2014-12-30 00:00:00

abstract：:The objective was to quantify drug loss due to cold flow (CF) in marketed estradiol transdermal drug delivery systems (TDDS), and study its influence on the in vitro flux and drug transfer across contacting skin. TDDS samples (products-A and B) were induced with CF at 25 and 32°C/60% RH by applying 1-kg force for 72h....

journal_title：International journal of pharmaceutics

authors： Krishnaiah YS,Yang Y,Hunt RL,Khan MA

更新日期：2014-12-30 00:00:00

abstract：UNLABELLED:This work describes innovative niosomes, composed of diolein alone or in association with the hydrophilic penetration enhancer Labrasol(®), as carriers for cutaneous drug delivery. The model drug was tretinoin and conventional, and Labrasol(®) containing liposomes was used as controls to evaluate the influen...

journal_title：International journal of pharmaceutics

authors： Manca ML,Manconi M,Nacher A,Carbone C,Valenti D,Maccioni AM,Sinico C,Fadda AM

更新日期：2014-12-30 00:00:00

abstract：:Infection still present as one of common complications after total hip replacement (∼2.5%), which may cause serious outcomes. For preventing such risk, loading antibiotics onto implants for increasing local drug concentration at targeted sites could be a solution. This study aims at modifying the surface of hydroxyapa...

journal_title：International journal of pharmaceutics

authors： Taha M,Chai F,Blanchemain N,Neut C,Goube M,Maton M,Martel B,Hildebrand HF

更新日期：2014-12-30 00:00:00

abstract：:In the pharmaceutical field, manufacturing processes which are able to make products with tailored size at suitable shear stress conditions and high productivity are important requirements for their industrial application. Cross-flow and premix membrane emulsification are the membrane-based processes generally used fo...

journal_title：International journal of pharmaceutics

authors： Imbrogno A,Piacentini E,Drioli E,Giorno L

更新日期：2014-12-30 00:00:00

abstract：:The aim of the current study is to explore the potential of PEG-30-dipolyhydroxystearate (Cithrol(®) DPHS) and Soluplus(®) as ingredients in novel semisolid self-nanoemulsifying drug delivery systems (SNEDDS). Semisolid SNEDDS consisting of Cithrol(®) DPHS, Capmul(®) MCM and Kolliphor(®) HS 15 were successfully prepar...

journal_title：International journal of pharmaceutics

authors： Hassan TH,Metz H,Mäder K

更新日期：2014-12-30 00:00:00

abstract：:The aim of the present work was to develop and assess the potential of nanostructured lipid carriers (NLCs) loaded with methotrexate as a new approach for topical therapy of psoriasis. Methotrexate-loaded NLCs were prepared via a modified hot homogenization combined with ultrasonication techniques using either polysor...

journal_title：International journal of pharmaceutics

authors： Pinto MF,Moura CC,Nunes C,Segundo MA,Costa Lima SA,Reis S

更新日期：2014-12-30 00:00:00

abstract：:This study aims to improve understanding of the powder fluidisation and aerosolisation processes unique to a split capsule dry powder inhaler. It uses a combination of dynamic real-time methods and a suite of powder material physicochemical characterisation methods. The study focused on examining the effect of differe...

journal_title：International journal of pharmaceutics

authors： Sim S,Margo K,Parks J,Howell R,Hebbink GA,Orlando L,Larson I,Leslie P,Ho L,Morton DA

更新日期：2014-12-30 00:00:00

abstract：:This paper describes a rational method of characterizing the biopharmaceutical stability of two oral suspensions of ursodeoxycholic acid (UDCA) used in pediatrics. Because there is no commercial presentation of UDCA that can administer appropriate doses for infants and children, an active pharmaceutical ingredient (AP...

journal_title：International journal of pharmaceutics

authors： Santoveña A,Sánchez-Negrín E,Charola L,Llabrés M,Fariña JB

更新日期：2014-12-30 00:00:00

abstract：:This paper describes a systematic approach to select optimum stabilizer for the preparation of nano-crystalline suspensions of an active pharmaceutical ingredient (API). The stabilizer can be either a dispersant or a combination of dispersant and wetting agent. The proposed screening method is a quick and efficient wa...

journal_title：International journal of pharmaceutics

authors： Nakach M,Authelin JR,Tadros T,Galet L,Chamayou A

更新日期：2014-12-10 00:00:00

abstract：:Oral absorption of lopinavir (LPV) is limited due to P-glycoprotein (P-gp) and multidrug resistance-associated protein2 (MRP2) mediated efflux by intestinal epithelial cells. Moreover, LPV is extensively metabolized by CYP3A4 enzymes. In the present study, dipeptide prodrug approach was employed to circumvent efflux p...

journal_title：International journal of pharmaceutics

authors： Patel M,Sheng Y,Mandava NK,Pal D,Mitra AK

更新日期：2014-12-10 00:00:00

abstract：:TXA497 is representative of a new class of guanidinomethyl biaryl compounds that exhibit potent bactericidal behavior against methicillin-resistant Staphylococcus aureus (MRSA). In this study, we compared the anti-staphylococcal, skin deposition, and skin permeation properties of TXA497 and the topical anti-MRSA antib...

journal_title：International journal of pharmaceutics

authors： Dorrani M,Kaul M,Parhi A,LaVoie EJ,Pilch DS,Michniak-Kohn B

更新日期：2014-12-10 00:00:00

abstract：:This work examines the influence of essential oil composition on emulsification with rhamnolipids and their use as therapeutic antimicrobial agents against two opportunistic pathogens, methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans. Rhamnolipids, produced by Pseudomonas aeruginosa, with waste ...

journal_title：International journal of pharmaceutics

authors： Haba E,Bouhdid S,Torrego-Solana N,Marqués AM,Espuny MJ,García-Celma MJ,Manresa A

更新日期：2014-12-10 00:00:00

abstract：:Clinical performance of an amorphous solid dispersion (ASD) drug product is related to the amorphous drug content because of the greater bioavailability of this form of the drug than its crystalline form. Therefore, it is paramount to monitor the amorphous and the crystalline fractions in the ASD products. The objecti...

journal_title：International journal of pharmaceutics

authors： Rahman Z,Siddiqui A,Bykadi S,Khan MA

更新日期：2014-11-20 00:00:00

abstract：:Postcataract endophthalmitis treatment through eye drops is of low corneal bioavailability and short residence time. The dominant NSAIDs therapy also suffers from severe ocular irritancy and low patients compliance. This study dispersed bovine serum albumin (BSA) coated meloxicam (MX) nanocrystals encapsulating nanoag...

journal_title：International journal of pharmaceutics

authors： Zhang W,Zu D,Chen J,Peng J,Liu Y,Zhang H,Li S,Pan W

更新日期：2014-11-20 00:00:00

abstract：:Personalized medicine is a challenging research area in paediatric drug design since no suitable pharmaceutical forms are currently available. Furosemide is an anthranilic acid derivative used in paediatric practice to treat cardiac and pulmonary disorders in premature infants and neonates. However, it is not commerci...

journal_title：International journal of pharmaceutics

authors： Provenza N,Calpena AC,Mallandrich M,Sánchez A,Egea MA,Clares B

更新日期：2014-11-20 00:00:00

abstract：:The establishment of physiologically relevant in vitro-in vivo correlations (IV-IVCs) is key for any biorelevant dissolution test. Historically, bicarbonate buffers have produced better correlations than compendial phosphate buffered media, though such tests are usually performed at a constant pH experiment, overlooki...

journal_title：International journal of pharmaceutics

authors： Merchant HA,Goyanes A,Parashar N,Basit AW

更新日期：2014-11-20 00:00:00

abstract：:The purpose of this study is to establish a novel approach for preparing a solid dispersion drug product using spherical silicate by a Wurster-type fluidized bed granulator. The spherical silicate used in this study has porous structure and ideal particle size for loading by a Wurster-type fluidized bed granulator. As...

journal_title：International journal of pharmaceutics

authors： Nagane K,Kimura S,Ukai K,Ogawa N,Yamamoto H

更新日期：2014-11-20 00:00:00

abstract：:Phenothiazine drugs - chlorpromazine (CPZ), promazine (PZ) and promethazine (PMZ) - were exposed to 266 nm (fourth harmonic of the Nd:YAG pulsed laser radiation) in order to be modified at molecular level and to produce an enhancement of their antibacterial activity. The irradiated samples were analysed by several met...

journal_title：International journal of pharmaceutics

authors： Simon A,Alexandru T,Boni M,Damian V,Stoicu A,Dutschk V,Pascu ML

更新日期：2014-11-20 00:00:00

abstract：:The combination of a highly soluble salt form of a drug with a polymeric precipitation inhibitor has the potential to prolong drug supersaturation even following salt disproportionation. In this study, dissolution profiles of ibuprofen sodium in the presence of various cellulosic polymers, including hydroxypropyl meth...

journal_title：International journal of pharmaceutics

authors： Terebetski JL,Michniak-Kohn B

更新日期：2014-11-20 00:00:00

abstract：:Biocompatible microemulsions composed of Peceol(®), lecithin, ethanol and water developed for encapsulation of hydrophilic drugs were investigated. The binary mixture Peceol(®)/ethanol was studied first. It was shown that the addition of ethanol to pure Peceol(®) has a significant fluidifying and disordering effect on...

journal_title：International journal of pharmaceutics

authors： Mouri A,Diat O,Lerner DA,El Ghzaoui A,Ajovalasit A,Dorandeu C,Maurel JC,Devoisselle JM,Legrand P

更新日期：2014-11-20 00:00:00

abstract：:The objective of this study was to construct a new in situ gel system based on the combination of poloxamer 407 and carrageenan (carrageenan-poloxamer 407 hydrogel, CPH) for intranasal delivery of ketorolac tromethamine. CPH showed potassium ion concentration - dependent erosion characteristics which ensured slow eros...

journal_title：International journal of pharmaceutics

authors： Li C,Li C,Liu Z,Li Q,Yan X,Liu Y,Lu W

更新日期：2014-10-20 00:00:00

abstract：:The implementation of a blend monitoring and control method based on a process analytical technology such as near infrared spectroscopy requires the selection and optimization of numerous criteria that will affect the monitoring outputs and expected blend end-point. Using a five component formulation, the present arti...

journal_title：International journal of pharmaceutics

authors： Igne B,de Juan A,Jaumot J,Lallemand J,Preys S,Drennen JK,Anderson CA

更新日期：2014-10-01 00:00:00

abstract：:The present study reports the production and characterization of PEG-coated silica nanoparticles (SiNP-PEG) containing insulin for oral administration. High (PEG 20,000) and low (PEG 6000) PEG molecular weights were used in the preparations. SiNP were produced by sol-gel technology followed by PEG adsorption and chara...

journal_title：International journal of pharmaceutics

authors： Andreani T,de Souza AL,Kiill CP,Lorenzón EN,Fangueiro JF,Calpena AC,Chaud MV,Garcia ML,Gremião MP,Silva AM,Souto EB

更新日期：2014-10-01 00:00:00

abstract：:The saturation solubilities of nicotine and scopolamine bases as well as acidic paracetamol were measured in two different model stratum corneum lipid matrices. Light microscopy visualized the presence of drug above its solubility either as droplets or crystalline particles. Neither wide-angle X-ray diffraction nor DS...

journal_title：International journal of pharmaceutics

authors： Mundstock A,Lee G

更新日期：2014-10-01 00:00:00

abstract：:The aim of this study was to develop a sensitive and discriminative in vitro-in silico model able to simulate the in vivo performance of three fenofibrate immediate release formulations containing different surfactants. In addition, the study was designed to investigate the effect of dissolution volume when predicting...

journal_title：International journal of pharmaceutics

authors： Berthelsen R,Sjögren E,Jacobsen J,Kristensen J,Holm R,Abrahamsson B,Müllertz A

更新日期：2014-10-01 00:00:00

abstract：:Microemulsions show significant promise for enhancing the oral bioavailability of biopharmaceutics classification system (BCS) class II drugs, but how about class III drugs remains unclear. Here we employed metformin hydrochloride (MET) as the model drug and prepared drug-loaded water-in-oil (W/O) microemulsions selec...

journal_title：International journal of pharmaceutics

authors： Li Y,Song J,Tian N,Cai J,Huang M,Xing Q,Wang Y,Wu C,Hu H

更新日期：2014-10-01 00:00:00

abstract：:Amphotericin B (AmB) has a broad antifungal and leishmanicidal activity with low incidence of clinical resistance. Its parenteral administration has high risk of nephrotoxicity that limits its use. In order to treat cutaneous infections, AmB topical administration is a safer therapy because of the low systemic absorpt...

journal_title：International journal of pharmaceutics

authors： Ruiz HK,Serrano DR,Dea-Ayuela MA,Bilbao-Ramos PE,Bolás-Fernández F,Torrado JJ,Molero G

更新日期：2014-10-01 00:00:00

abstract：:Silk fibroin (SF) and poly(lactide-co-glycolic acid) (PLGA) have been proved to be invaluable polymers in the field wound healing. This study aims at optimizing the electrospinning process of those polymers to make a hybrid membrane as a chronic wounds dressing. After characterizing the scaffolds, PLGA/SF (2:1), and P...

journal_title：International journal of pharmaceutics

authors： Shahverdi S,Hajimiri M,Esfandiari MA,Larijani B,Atyabi F,Rajabiani A,Dehpour AR,Gharehaghaji AA,Dinarvand R

更新日期：2014-10-01 00:00:00

abstract：:The current work aimed to develop novel composite sponges of chitosan (CH)-chondroitin sulfate (CS) as a low-density gastroretentive delivery system for lornoxicam (LOR). This triple anti-inflammatory therapy-loaded matrices are expected to expand and float upon contact with gastric fluids for prolonged times. CH and ...

journal_title：International journal of pharmaceutics

authors： Tadros MI,Fahmy RH

更新日期：2014-09-10 00:00:00

abstract：:This review aims to give to the reader some new light on cyclodextrin (CD)-based theranostic agents in order to complete our recently published review dedicated to CD-particles conjugates in drug delivery systems (Zafar et al., 2014). CDs are biocompatible sugar-based macrocycles used in a wide range of biomedical app...

journal_title：International journal of pharmaceutics

authors： Zafar N,Fessi H,Elaissari A

更新日期：2014-09-10 00:00:00

abstract：:Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-lo...

journal_title：International journal of pharmaceutics

authors： Kurczewska J,Lewandowski D,Olejnik A,Schroeder G,Nowak I

更新日期：2014-09-10 00:00:00

abstract：:Docetaxel (DTX) remains the only effective drug for prolonging survival and improving quality of life of metastatic castration resistant prostate cancer (mCRPC) patients. Despite some clinical successes with DTX-based therapies, advent of cumulative toxicity and development of drug resistance limit its long-term clini...

journal_title：International journal of pharmaceutics

authors： Hoang B,Ernsting MJ,Murakami M,Undzys E,Li SD

更新日期：2014-08-25 00:00:00

abstract：:Microemulsions show excellent potential as drug delivery systems, but the surfactants used to prepare them can cause side effects. Researchers have explored various strategies to expand microemulsion area and thereby reduce the surfactant content necessary, but how these strategies affect drug oral bioavailability has...

journal_title：International journal of pharmaceutics

authors： You X,Xing Q,Tuo J,Song W,Zeng Y,Hu H

更新日期：2014-08-25 00:00:00